A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells.
The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle.
Now researchers from the Peter Doherty Institute for Infection and Immunity in Melbourne, have demonstrated a way to make the virus visible, paving the way to fully clear it from the body.
It is based on mRNA technology, which came to prominence during the Covid-19 pandemic when it was used in vaccines made by Moderna and Pfizer/BioNTech.
In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.
hm i wonder if something like thia could be done for other viruses that hide, like e.g. herpes
Interesting question. Altough trying this with HIV first is a good first choice in term of priority.
absolutely. it was just the first virus that came to mind other than hiv
Or Epstein -Barr. Or Varicella.
Eliminating all of those would be great.
mRNA
better not be in the US for this, especially with the MAHA boss being a HIV denier.Melbourne
Good.
the paper in question: Efficient mRNA delivery to resting T cells to reverse HIV latency by Paula M. Cevaal et al.
Would be amazing if this also works for other hiding viruses , maybe even long covid?
That’s promising but the cure is years aways, if possible at all.
Until then, keep using condoms and/or PreP.
Further research will be needed to determine whether revealing the virus is enough to allow the body’s immune system to deal with it, or whether the technology will need to be combined with other therapies to eliminate HIV from the body.
The study is laboratory based and was carried out in cells donated by HIV patients. The path to using the technology as part of a cure for patients is long, and would require successful tests in animals followed by safety trials in humans, likely to take years, before efficacy trials could even begin.
Even if we cured HIV, there are still plenty of other diseases you should wear a condom for!
Like antibiotic resistant gonorrhea and clamidya. Noone wants to get those.
I sorta hate articles like this because I know if will fuel the maga/qanon/dumbshit crowd to be even more against mRNA based things. We need more articles on its use in cancer although what am I saying. Im sure they likely have some dumbass reasoning around cancer as well.
The end-times death cult doesn’t want any medical breakthroughs at all. But fuck em. Everywhere without these freaks should keep up the good research unabashed.
This is a huge stepping stone to a final cure
