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Every plant is poisonous. Humans are basically the only mammal that eats capsaicin, caffeine, menthol. Grapes are toxic for everything except a few things. Plants don’t have the ability to pull out a gun to defend itself and so it uses poison, or irritants like thorns. This isn’t limited to pants with animals. Plants are also toxic to other plants. The example that I deal with the most is black walnut. I tried growing plants and when I used the walnut leaves for mulch it would kill the plants I tried growing.
I usually avoid stuff labeled “for men” because it’s usually a lower quality product but that allows it to be also labeled “rugged”