Yes, by organizing at the grassroots level in Texas, Wisconsin, North Carolina, Maine, and Georgia so that they send two blue Senators to Congress every single year. Vote totals in those areas are close enough to overcome the GOP’s structural advantages, but it will require a ground-up operation that bridges the divide between different coalitions on the left and builds a deep bench of community-connected candidates with good name recognition.
That’s a good point. Independents and third party candidates should ABSOLUTELY run for Senate in deep red states. They don’t have the cultural baggage of being a Democrat, and so they can triangulate on platform issues in a way that a party-affiliated Democrat couldn’t, and in so doing they might actually be able to exploit GOP candidate weaknesses with centrist or disaffected voters.