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Joined 1 year ago
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Cake day: September 26th, 2023

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  • I benefit from an orphan drug, and the R&D was most definitely subsidised by the public purse.

    My insurance pays a few grand a month for it.

    The mfg coupon covers most of the rest, minus a copay.

    This is the second iteration of the original drug. The first hasn’t meaningfully fallen in price and only the original company can manufacture and distribute the generic even under the name of competitors.

    There was no breakthrough in the second iteration, and the logic to solve the “problem” they solved was straightforward. So now I pay more, for an anecdotally less effective version that addresses a risk irrelevant to me but present in the original.

    There is yet a third iteration on the way.

    Shock revelations:

    • pharma companies are greedy and will double dip against both government subsidies and patients/insurance at every opportunity.
    • XX Pharma didn’t pay for the original R&D, my gov did.
    • if one replaces Na with a/several similar elements, one still ends up with a salt, often resulting in a drug variant that “doesn’t affect blood pressure” and offers no other real benefits, nor risks.
    • Clinical trials for said alternative salt are broadly leas expensive than for the original. That does not result in lower prices.

    Nationalise pharma research, if not the manufacturers.

    Also, generics are often manufactured in countries with, shall we say, fewer controls and regulations. Know who makes those pills and where. If you can’t stomach the FDA reports on that manufacturer, find a pharmacy who will sell you something else…



  • Generally? Well within the executive power / administrative law of any given state as noted by BlueFalcon below.

    Practically? I’d expect it to be quite a struggle. For licensed professions in general (doctors, real estate, insurance, hairdressers, etc.) most or all states ask a question to the effect of “Has your license for profession ever been suspended or revoked in any other state?”. It may or may not be an automatic disqualifier, but even if not it’s an uphill battle.

    It prevents the real estate agent who stole someone’s earnest money from upping stakes to the next state and getting licensed, but since the standards for suspending/revoking licenses vary widely by state I lean towards believing that perhaps it should be a factor, and perhaps the state board of profession should meet to review the application, but previous disciplinary action in some other state is in no way an absolute statement about someone’s fitness to practice in their chosen field.





  • It’s already trivial to get local banking details from many countries, (e.g., ‘multi-currency’ debit cards) but as far as I’m aware there’s not a practical way to get a foreign debit card without the usual hoops that the full account would require.

    Probably because demand for such a thing is low - I can generate disposable card numbers on the fly, but only from my home country. Can’t imagine (aside from this specific edge case in question) generating foreign card numbers would be all that useful most of the time.

    End-user support for such a thing would also be a challenge - I’m very accustomed to entering the usual data points with my card, but users would forget the associated postal code, or any number of other things, and then call support whining that it’s ‘broken’.




  • At least one giant multi-national corp is actively soliciting examples and use cases from their employees.

    “Toy” example submissions is fine, the company is just so eager for something to do with AI - they’re hoping for their actual AI folks to be able to take off of that uncompensated IP, while the employee with the idea gets a pat on the head.

    Have I had ideas I might otherwise submit and that are well within my capabilities to implement at “toy” level? Hell, yes.

    Do I want to contribute concepts into that sort of pipeline? Absolutely not. Not when they more or less automatically own my work product and whatever I do on company time already.




  • In green fields projects, this makes a fair bit of sense at initial reading, tentatively.

    But new code becomes old code, and then builds on the quality / discipline / cowboy status of the last person to touch the code, in a complex and interlocking way.

    I can’t say I’d be excited to find a partially converted existing codebase of this. But in fairness, I’m on my couch on a Sunday and haven’t actually worked through your examples (or read the original paper). I see the benefit to having both types of extensibility, obviously. Just not sure it outweighs the real world risk once actual humans start getting involved.

    I don’t know a single person who can’t say they’ve never taken a single “good enough” shortcut at work, ever, and it seems this only works (efficiently) if it’s properly and fully implemented.





  • Elsewhere, someone suggested that it would be necessary to take the rebuild down to the dirt to handle plumbing and the like for individual units, but I’m not sure I agree.

    Generally there is significant excess ceiling height in these commercial spaces, no reason the floor couldn’t be raised throughout the space to accommodate plumbing and the like in a way that’s easily accessible for future maintenance. You still end up with 8’ ceilings (or probably rather more) throughout.

    Over the years, I’ve watched a number of retail chains and malls die, sometimes suddenly and sometimes slowly. It’s continuously seemed like a huge waste to me, when conversion to residential space would be relatively easy, relatively affordable, could be funded by local gov or nonprofit, and would make a significant difference in net housing costs in a given area.

    When ‘traditional’ residential developers are competing with that, and with the ability to slap down standard-sized (AKA easy) risers/walls/etc. within commercial spaces of defined sizes, a further reduction in local housing costs is likely.


  • Woah, that’s absolutely insane. Subway has always struck me as a little pricey for what they offer, but they’re also dead consistent which counts for something.

    JJs, no way I’d spent $26 for a sandwich of any size.

    At those prices (or McDonald’s prices these days, TBH), I’d just as soon sit down and also tip for basically the same amount of money with better quality food.

    Self-checkout tipping has never made sense to me. I haven’t done the deep dive research, but I suspect that since the tips are not directed at an employee, it’s an easy way for the business itself to get tips w/o being in violation of tip theft laws. No intended employee recipient == free-for-all and business can grab the cash.