I assumed you were getting downvoted initially for the disingenuous “both sides” rhetoric which is a non-point that has been gone over in detail here ad nauseum, and then subsequently because you doubled down by implying if people downvoted your first point, it means they think politicians have their best interests in mind. I don’t think anyone believes that, so it kind of reads like you’re tilting at windmills.
Great writing! This reminds me of Amy Hempel.
There’s the rub. The outdoors and land in BIBN are beautiful and inexpensive but you have the local wildlife bigotry to contend with.
If he’s really dosing ketamine, it feels odd that he can’t seem to develop any sense of oneness with the universe, awareness of the innate value of other people, empathy for them, and self-humility. I guess it affects people differently, but what’s it actually doing for him?
It should say inflation-causing.
F I R E F O X already
No one is denying Raytheon makes things for the military, that can only be used by the military, and test those things in conjunction with the military in military bases, and get special dispensation to sell them to allied militaries, but they are not part of the military and also make many things that are sold commercially. And, some of the things they invented and used to be sold only to the military have resulted in civilian applications and are sold to normal people.
An example: they spun off their air conditioning business to a separate company years back, it was huge news. Maybe you have heard of them: Amana? Later owned by Maytag and now Whirlpool? Are those part of the military? You can’t enlist to be a Raytheon employee just like you can’t enlist to be an Amana employee.
You know who else makes many things for the military? Lighthouse for the Blind, an organization that employs and trains many vision- and hearing-impaired people. But they’re also not part of the military. And same thing with many other companies that bid for and win military contracts to provide many different items that are also sold to civilians.
They are not military, but they have had many huge military contracts over the years and work closely with the military. They also invented the microwave oven and many other commercial non-military electronics.
A scorpion is not a dogshit human being who makes conscious decisions to kill other human beings.
I hadn’t considered that, but now I will.
Not sure how to feel about TS; on the one hand she can bring positive change on small economic issues related to entertainment like this, on the other hand her carbon footprint is inexcusable and she’s as much if not more of a blight on the environment as any other billionaire I can think of.
Cumberland County Sheriff Kevin Joyce said in an earlier statement that an internal investigation had cleared his officers and that no one was determined to be intoxicated at the scene. He said any report of intoxicated officers should have been raised at the time, not six months afterwards.
There it is, the cops drunk driving an armored vehicle and nearly crashing into another emergency vehicle are cleared of all wrongdoing because they said they weren’t intoxicated. 'K.
“It was a joke.” If you have to explain that something is a joke, you either need to work on your setup and delivery, or it’s only a joke in your own mind.
I would go even harder and say the formal/semi-formal/business/casual folkways are outdated and I wish those expectations or requirements didn’t exist. My work dress policy for the office doesn’t allow sweatpants or yoga pants, but jeans and khakis are fine if you aren’t “client-facing.” Fine, but in jeans or khakis I will be adjusting far more often and imo that’s less professional than just wearing more comfortable clothes.
“Underground economy.” Right…Nothing happens in China for long that the CCP doesn’t approve of, for a price.
You said, it is easy and inexpensive to manufacture generics and that the expense for drug production goes into research.
Did you not read the article you linked, or did you just not read my comment before downvoting it? It says the exact same thing in the “Controversies in FDA Bioequivalence Testing” section about the efficacy of the drug I listed as a specific example of generics not actually showing bioequivalence…TSH, free T4, and T3 in the blood are how the efficacy of levothyroxine is measured. Here, I’ll quote it for you.
Unresolved concerns surrounding bioequivalence undermine patients’ and health care providers’ confidence in making generic substitutions. Bioequivalence studies do not assess clinical or surrogate markers that directly correlate with efficacy and/or toxicity (e.g., thyroid-stimulating hormone [TSH], seizures, transplant rejection, international normalized ratio). In addition, manufacturers do not undertake comparative studies against other generic products with the same active ingredient, yet the FDA maintains that all approved generic medications are bioequivalent
That’s simply not true. Scale up and manufacturing of even the simplest small-molecule drugs even after all the clinical research has been completed is incredibly complex and hard to manufacture consistently, let alone replicate.
Even with access to all the research and manufacturing and quality testing procedures and records of a successfully manufactured drug (which a generic competitor would not have), I have seen and been part of an expansion facility at the very same location using the exact same raw material suppliers and exact same serial # equipment and even the same cleaning and manufacturing and quality testing lab employees just moved into a new building, take years and dozens of batches to get to the same level of consistent safety, identity, strength, purity, and quality as the previous manufacturing line after it was shut down to make room for a newer product. I’ve seen final product yield drop by nearly half from batch to batch just because the supplier of one raw material used as an excipient switched their own manufacturing process to make a powder slightly more consistently fine-grained and the mixing process no longer worked the same - and it took months of investigation to figure that out, plus much more time and money to find a solution and demonstrate it didn’t change the final product over the next three batches (a regulatory requirement).
Change over to modern large-molecule biologics where you have to grow them up in bioreactors, and things get a lot more complex to get it right and even harder to get consistent. You can’t just follow a recipe and double the ingredients to get twice the product.
Consider an extremely common drug like levothyroxine that’s been around for nearly a century and has many generic manufacturers because it’s one of the “easiest” and most well-understood essential drugs to make. It has such a low therapeutic window that the exact same process between two manufacturers, using the exact same raw material suppliers, passing testing with the exact same results, can result in such drastically inconsistent levels in the same patient at the exact same dose that many people are unable to switch from a one generic or brand manufacturer to another once their doctor has managed to find the right dose to keep their T4 levels stable. Something as mundane as the shape of the tablet press can make a huge difference even when dissolution is the same.
It’s not at all easy to manufacture drugs.
One of the dumbest social standards taught to kids that empowers bullies and bolsters peer pressure.
5k people is a bigger population than many towns yes, but crammed into a 250x250x1100 foot box in the biggest case (Ford class)